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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WWOX All Species: 6.06
Human Site: S110 Identified Species: 10.26
UniProt: Q9NZC7 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZC7 NP_057457.1 414 46677 S110 T R Q R Y D G S T T A M E I L
Chimpanzee Pan troglodytes XP_001144696 363 41022 V73 E T D E N G Q V F F V D H I N
Rhesus Macaque Macaca mulatta XP_001105944 398 45056 D108 P S T Q Q R Y D G S T T A M E
Dog Lupus familis XP_852623 383 43043 T93 L D P R L A F T V D D N P T K
Cat Felis silvestris
Mouse Mus musculus Q91WL8 414 46494 S110 T R Q R Y D G S T T A M E I L
Rat Rattus norvegicus NP_001099658 356 40173 E66 L P Y G W E Q E T D E N G Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505354 146 16628
Chicken Gallus gallus Q5F389 414 46711 N110 T R Q K Y D G N S T A M E I L
Frog Xenopus laevis NP_001088080 143 16305
Zebra Danio Brachydanio rerio Q803A8 412 46303 A110 R Y D G N T G A L E I L H G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLU5 409 46492 V113 S C S T A L Q V L H G K D L H
Honey Bee Apis mellifera XP_395282 414 46992 A109 R F D G S S T A L S V L H G R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789399 410 45991 T110 Q R F D A Y S T A L H V L Q G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42536 405 43844 A109 S G L G L A T A K A L A E T G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.5 84.7 82.8 N.A. 93.7 81.1 N.A. 26 83 29.2 71.9 N.A. 48.3 51.2 N.A. 56.2
Protein Similarity: 100 86.2 88.4 87.4 N.A. 96.1 83.8 N.A. 29.4 93 33.3 84.3 N.A. 65.2 66.6 N.A. 73.4
P-Site Identity: 100 6.6 0 6.6 N.A. 100 6.6 N.A. 0 80 0 6.6 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 6.6 20 13.3 N.A. 100 26.6 N.A. 0 100 0 20 N.A. 20 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 28.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 15 15 0 22 8 8 22 8 8 0 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 22 8 0 22 0 8 0 15 8 8 8 0 0 % D
% Glu: 8 0 0 8 0 8 0 8 0 8 8 0 29 0 8 % E
% Phe: 0 8 8 0 0 0 8 0 8 8 0 0 0 0 0 % F
% Gly: 0 8 0 29 0 8 29 0 8 0 8 0 8 15 15 % G
% His: 0 0 0 0 0 0 0 0 0 8 8 0 22 0 8 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 0 29 0 % I
% Lys: 0 0 0 8 0 0 0 0 8 0 0 8 0 0 8 % K
% Leu: 15 0 8 0 15 8 0 0 22 8 8 15 8 8 22 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 22 0 8 0 % M
% Asn: 0 0 0 0 15 0 0 8 0 0 0 15 0 0 8 % N
% Pro: 8 8 8 0 0 0 0 0 0 0 0 0 8 0 0 % P
% Gln: 8 0 22 8 8 0 22 0 0 0 0 0 0 15 8 % Q
% Arg: 15 29 0 22 0 8 0 0 0 0 0 0 0 0 8 % R
% Ser: 15 8 8 0 8 8 8 15 8 15 0 0 0 0 0 % S
% Thr: 22 8 8 8 0 8 15 15 22 22 8 8 0 15 0 % T
% Val: 0 0 0 0 0 0 0 15 8 0 15 8 0 0 8 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 8 0 22 8 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _